Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Amygdala kindling elevates plasma vasopressin.

R S Greenwood1, R B Meeker, J N Hayward

  • 1Department of Neurology and Curriculum of Neurobiology, School of Medicine, University of North Carolina, Chapel Hill 27599-7025.

Brain Research
|January 4, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synthetic amyloid beta does not induce a robust transcriptional response in innate immune cell culture systems.

Journal of neuroinflammation·2022
Same author

Astrocytes and microglia differentially regulate trafficking of lymphocyte subsets across brain endothelial cells.

Brain research·2005
Same author

Development of neuronal sensitivity to toxins in cerebrospinal fluid from HIV-type 1-infected individuals.

AIDS research and human retroviruses·2004
Same author

Infection of the choroid plexus by feline immunodeficiency virus.

Journal of neurovirology·2002
Same author

Choroid plexus macrophages proliferate and release toxic factors in response to feline immunodeficiency virus.

Journal of neurovirology·2002
Same author

Destabilization of neuronal calcium homeostasis by factors secreted from choroid plexus macrophage cultures in response to feline immunodeficiency virus.

Neurobiology of disease·2002
Same journal

IGFBP3 and UBE2C are associated with protein modification pathways and serve as prognostic markers in glioma.

Brain research·2026
Same journal

Targeting neurodevelopmental miR132-3p promotes neuroprotection and axon regeneration after optic nerve injury in mice.

Brain research·2026
Same journal

Variability in acoustic startle response and prepulse inhibition across adulthood in Fragile X messenger ribonucleoprotein 1 knockout mice.

Brain research·2026
Same journal

Transcriptome-guided modeling reveals insulin-related metabolic dysfunction in SCA3 mouse cerebellum.

Brain research·2026
Same journal

Intranasal stromal cell-derived factor-1α mitigates parkinsonian deficits via dual modulation of neuroinflammation and gut microbiota in MPTP-induced models.

Brain research·2026
Same journal

Emotions, the amygdala, and the right hemisphere.

Brain research·2026
See all related articles

Epilepsy and amygdala stimulation can acutely increase vasopressin (antidiuretic hormone) release. Kindling epilepsy causes persistent changes in this neuroendocrine system, affecting vasopressin levels.

Area of Science:

  • Neuroendocrinology
  • Epilepsy Research
  • Neuroscience

Background:

  • Epilepsy, particularly limbic seizures, affects endocrine function.
  • The amygdala, crucial in the limbic system, influences vasopressin release via hypothalamic connections.

Purpose of the Study:

  • To investigate acute vasopressin release following amygdala stimulation in rats.
  • To determine acute and chronic changes in vasopressin release in kindled animals.

Main Methods:

  • Blood samples were collected from rats with catheters before and after amygdala stimulation.
  • Plasma vasopressin, osmolality, and hematocrit were measured at various kindling stages.
  • Electrical stimulation (15 Hz and 60 Hz) was used to induce and study seizures.

Related Experiment Videos

Main Results:

  • Low-frequency amygdala stimulation caused a threefold increase in plasma vasopressin.
  • Seizures in kindled rats (stage 5) significantly elevated plasma vasopressin post-stimulation.
  • Kindling led to a modest, persistent rise in resting vasopressin without altering osmolality or hematocrit.

Conclusions:

  • Amygdala stimulation acutely releases vasopressin.
  • Epileptic kindling induces lasting alterations in the vasopressinergic neuroendocrine system.