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Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
Published on: February 23, 2014
[Pneumococcal pneumonia highly probable in immunized children cared for in-group settings]
D Gendrel1, C Vallet, C Gelmetti
1Service de pédiatrie, université Paris 5, hôpital Saint-Vincent-de-Paul, 82, avenue Denfert-Rochereau, 75014 Paris, France. dominique.gendrel@svp.ap-hop-paris.fr
Pneumococcal conjugate vaccine reduced invasive pneumococcal disease, but pneumonia in vaccinated children persists, especially in group settings. High procalcitonin and C-reactive protein levels predict pneumococcal pneumonia in young children.
Area of Science:
- Pediatrics
- Infectious Diseases
- Vaccinology
Background:
- Invasive pneumococcal diseases (IPD) decreased post-pneumococcal conjugate vaccine (PCV) introduction.
- Non-vaccine serotype infections and community-acquired pneumonia (CAP) remain concerns.
- Predicting pneumococcal CAP requires specific clinical and laboratory markers.
Purpose of the Study:
- To evaluate the occurrence of pneumococcal pneumonia in young children after PCV widespread use.
- To identify risk factors for pneumococcal pneumonia in vaccinated children.
Main Methods:
- Retrospective analysis of 259 children under 7 hospitalized for CAP (2003-2008).
- Inclusion criteria: high procalcitonin and C-reactive protein, fever ≤48h post-antibiotics.
- Comparison of PCV-vaccinated vs. unvaccinated children, focusing on 2006-2008 cohort.
Main Results:
- 47 children met criteria for pneumococcal CAP.
- 27 cases occurred between 2006-2008 (post-PCV generalization).
- 21 of these 27 were PCV-vaccinated, with 19 attending group care settings.
Conclusions:
- Pneumococcal pneumonia can occur in PCV-immunized children.
- Group-care attendance is a significant risk factor for pneumococcal pneumonia in vaccinated children.
- Continued surveillance and potential vaccine updates are warranted.
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