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Related Experiment Video

Updated: Jun 15, 2026

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Published on: December 10, 2010

Purinergic signalling and bone remodelling.

Isabel R Orriss¹, Geoffrey Burnstock, Timothy R Arnett

¹Department of Cell and Developmental Biology, University College London, London, UK. i.orriss@ucl.ac.uk

Current Opinion in Pharmacology

|March 2, 2010

Summary

This summary is machine-generated.

Extracellular nucleotides, like ATP, significantly influence bone health by affecting bone-destroying osteoclasts and bone-forming osteoblasts. Understanding these P2 receptor-mediated effects is crucial for bone cell function research.

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A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

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Last Updated: Jun 15, 2026

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Published on: December 10, 2010

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

Area of Science:

Biochemistry
Cell Biology
Skeletal Biology

Background:

Extracellular nucleotides act as signaling molecules.
P2 receptors are involved in cellular communication.
Bone cells (osteoblasts and osteoclasts) are targets for extracellular signaling.

Purpose of the Study:

To review the current understanding of extracellular nucleotide effects on skeletal cells.
To highlight the role of P2 receptors in bone metabolism.

Main Methods:

Literature review of studies on extracellular nucleotides and bone cells.
Analysis of P2 receptor signaling pathways in osteoblasts and osteoclasts.

Main Results:

Extracellular nucleotides stimulate osteoclast formation and activity.
Nucleotides inhibit bone mineralization by osteoblasts.
P2 receptor activation mediates these effects on bone cells.

Conclusions:

Extracellular nucleotides play a significant role in modulating bone cell function.
P2 receptor signaling is a key pathway in regulating bone turnover.
Further research into nucleotide signaling may offer therapeutic targets for bone diseases.