Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bridging the gap in delirium management: a European comparison of geriatric practices.

European geriatric medicine·2026
Same author

GLO1 cg26053840 Methylation Associates with Kidney Injury and Inflammatory Markers in Hospitalized Older Adults.

Life (Basel, Switzerland)·2026
Same author

Age-adjusted leukocyte telomere length predicts long-term mortality in older patients discharged from acute care hospitals.

GeroScience·2026
Same author

Response to Boland et al. "Appraisal of the references supporting STOPP/START version 3 criteria".

European geriatric medicine·2026
Same author

Geriatric medicine across countries: Specialised workforce, training and system integration challenges.

The Journal of frailty & aging·2026
Same author

Caring for older adults in the Emergency Department: a Delphi-based national consensus by the Academy of Emergency Medicine and Care and the Italian Society of Gerontology and Geriatrics.

European geriatric medicine·2026

Related Experiment Video

Updated: Jun 15, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Hypertension and cognitive function in the elderly.

Antonio Cherubini1, David T Lowenthal, Esther Paran

  • 1Gerontology and Geriatrics, University of Perugia, Perugia, Italy.

Disease-A-Month : DM
|March 2, 2010
PubMed
Summary
This summary is machine-generated.

Managing hypertension and hyperglycemia is crucial for preventing vascular dementia in the elderly. Gradual blood pressure reduction is recommended to avoid worsening cognitive decline and stroke risk.

More Related Videos

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
06:58

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

Related Experiment Videos

Last Updated: Jun 15, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
10:13

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

Published on: February 14, 2014

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing
06:58

Highlighting and Reducing the Impact of Negative Aging Stereotypes During Older Adults' Cognitive Testing

Published on: January 24, 2020

Area of Science:

  • Neurology
  • Geriatrics
  • Cardiology

Background:

  • Alzheimer's disease and vascular dementia are leading causes of cognitive impairment in the elderly.
  • Hypertension and advanced age are significant risk factors for dementia, particularly vascular dementia.
  • Vascular dementia results from microangiopathy and white matter demyelination, often linked to uncontrolled hypertension.

Purpose of the Study:

  • To highlight the importance of managing hypertension and hyperglycemia in preventing vascular dementia.
  • To discuss the relationship between blood pressure control and cognitive decline in the elderly.
  • To differentiate vascular dementia from reversible causes of cognitive impairment.

Main Methods:

  • Review of existing studies (SHEP, SCOPE, HOPE) on blood pressure reduction and cognitive function.
  • Analysis of risk factors including age, hypertension, and hyperglycemia.
  • Examination of diagnostic criteria for vascular dementia.

Main Results:

  • Lowering blood pressure can prevent strokes but may not reverse existing microangiopathy leading to vascular dementia.
  • Gradual blood pressure reduction is advised due to age-related changes in cerebral autoregulation.
  • Control of blood glucose is essential in preventing vascular dementia associated with hyperglycemia.

Conclusions:

  • Effective management of hypertension and hyperglycemia is key to preventing vascular dementia.
  • Slow, controlled reduction of blood pressure is beneficial for elderly patients.
  • Understanding the diagnostic criteria is crucial for identifying vascular dementia and distinguishing it from other cognitive impairments.