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Local Anesthetics: Differential Sensitivity of Nerve Fibers

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Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...

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The site of chemical communication between a motor neuron and a muscle fiber is called the neuromuscular junction (NMJ). The end of the motor neuron at the NMJ divides into a cluster of synaptic end bulbs. The cytoplasm of these bulbs consists of synaptic vesicles enclosing acetylcholine molecules, the principal neurotransmitter released at the NMJ. The region opposite the synaptic bulb that ends in the muscle fiber is called the motor end plate, which has acetylcholine receptors. Within the...

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Related Experiment Video

Updated: Jun 15, 2026

Use of In Vivo Single-fiber Recording and Intact Dorsal Root Ganglion with Attached Sciatic Nerve to Examine the Mechanism of Conduction Failure

Use of In Vivo Single-fiber Recording and Intact Dorsal Root Ganglion with Attached Sciatic Nerve to Examine the Mechanism of Conduction Failure

Published on: August 27, 2019

Multifocal conduction blocks in sarcoid peripheral neuropathy.

Setsu Sawai¹, Sonoko Misawa, Makoto Kobayashi

¹Department of Neurology, Graduate School of Medicine, Chiba University.

Internal Medicine (Tokyo, Japan)

|March 2, 2010

Summary

Sarcoidosis can cause peripheral neuropathy, often leading to axonal damage. This study highlights three cases where sarcoidosis initially presented as multiple mononeuropathy with conduction blocks, which improved with corticosteroid treatment.

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Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat

Published on: November 21, 2025

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Last Updated: Jun 15, 2026

Use of In Vivo Single-fiber Recording and Intact Dorsal Root Ganglion with Attached Sciatic Nerve to Examine the Mechanism of Conduction Failure

Use of In Vivo Single-fiber Recording and Intact Dorsal Root Ganglion with Attached Sciatic Nerve to Examine the Mechanism of Conduction Failure

Published on: August 27, 2019

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat

Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat

Published on: November 21, 2025

Area of Science:

Neurology
Immunology
Pathology

Background:

Sarcoidosis is a multisystem inflammatory disease.
Peripheral neuropathy is a rare but recognized manifestation of sarcoidosis.
Previous research indicated axonal degeneration as the primary pathology in neurosarcoidosis.

Observation:

Three patients with sarcoidosis presented with multiple mononeuropathy as their initial symptom.
Nerve conduction studies revealed significant multifocal conduction blocks in the intermediate nerve trunks.
These conduction blocks were rapidly resolved following corticosteroid administration.

Findings:

The electrodiagnostic findings suggest demyelinative or ischemic-functional conduction blocks as the cause of neuropathy.
This presentation challenges the notion that axonal degeneration is the sole pathology.
The study identified three new cases of acute conduction block neuropathy in sarcoidosis.

Implications:

Acute conduction block neuropathy may be an underdiagnosed manifestation of sarcoidosis.
Early diagnosis and corticosteroid treatment can lead to significant clinical improvement.
Further research is warranted to understand the prevalence and mechanisms of conduction block in neurosarcoidosis.