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Updated: Jun 15, 2026
09:48
Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance
Published on: February 17, 2023
Type B insulin resistance complicated with systemic lupus erythematosus
Shin-Ya Kawashiri1, Atsushi Kawakami, Keita Fujikawa
1Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University.
Internal Medicine (Tokyo, Japan)
|March 2, 2010
Summary
Type B insulin resistance, marked by insulin receptor autoantibodies, was linked to active systemic lupus erythematosus (SLE) in a patient. Treatment for SLE resolved autoantibodies and improved glucose intolerance.
Area of Science:
- Endocrinology
- Immunology
- Rheumatology
Background:
- Type B insulin resistance is an autoimmune disorder featuring autoantibodies against the insulin receptor.
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse clinical manifestations.
Observation:
- A 59-year-old Japanese male presented with Type B insulin resistance and active systemic lupus erythematosus (SLE).
- High titers of anti-insulin receptor autoantibodies were detected during active SLE disease phases.
Findings:
- Treatment with intravenous cyclophosphamide, oral prednisolone, and cyclosporin A induced remission of SLE.
- Concurrently, anti-insulin receptor autoantibodies disappeared, leading to the resolution of glucose intolerance.
Implications:
- This case highlights a significant correlation between anti-insulin receptor autoantibodies in Type B insulin resistance and SLE disease activity.
- It suggests that managing SLE activity may be crucial for improving glycemic control in patients with this rare condition.
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