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Related Concept Videos

Yellow Fever01:18

Yellow Fever

Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...
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Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
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Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
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Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
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Related Experiment Video

Updated: Jun 15, 2026

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1
06:18

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Published on: March 13, 2018

Chikungunya fever from Malaysia.

Kouta Yamamoto1, Kentaro Matumoto, Chang-Kweng Lim

  • 1International Division of Internal Medicine, Kobe Kaisei Hospital. kokusai@kobe-kaisei.org

Internal Medicine (Tokyo, Japan)
|March 2, 2010
PubMed
Summary

A Malaysian woman contracted chikungunya virus (CHIKV) infection after returning from Kuala Lumpur to Japan. Diagnosis was confirmed through CHIKV RNA detection and subsequent antibody seroconversion.

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Mosquito-Associated Virus Isolation from Field-Collected Mosquitoes
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Mosquito-Associated Virus Isolation from Field-Collected Mosquitoes

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Last Updated: Jun 15, 2026

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1
06:18

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Published on: March 13, 2018

Mosquito-Associated Virus Isolation from Field-Collected Mosquitoes
06:41

Mosquito-Associated Virus Isolation from Field-Collected Mosquitoes

Published on: August 31, 2022

Area of Science:

  • Medical Entomology
  • Infectious Diseases
  • Virology

Background:

  • Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that causes febrile illness.
  • Recent outbreaks have expanded the geographic range of CHIKV, increasing the risk of imported cases.

Observation:

  • A Malaysian woman presented with dengue-like symptoms, including fever and arthritis, upon returning to Japan.
  • Initial diagnostic tests were negative, but subsequent testing confirmed chikungunya virus RNA in serum.

Findings:

  • The patient's serum tested positive for chikungunya virus (CHIKV) RNA.
  • IgM antibody against CHIKV was initially negative but seroconverted to positive within a week, confirming recent infection.
  • Symptoms, primarily arthralgia, resolved within 10 days.

Implications:

  • This case highlights the potential for imported chikungunya virus infections in non-endemic regions like Japan.
  • Early and accurate diagnosis of chikungunya is crucial for patient management and public health surveillance.
  • Understanding the clinical presentation and diagnostic timeline is essential for healthcare providers managing febrile illnesses in travelers.