Bone mineral content at three sites in normal perimenopausal women

Bone mineral content (BMC) in 217 healthy white women between the ages of 40 and 55 years was measured using single- and dual-photon absorptiometry. The sites measured included the distal radius, midradius, proximal femur, and lumbar spine. The relationship between BMC and age was constant over the age range studied when the confounding effect of menopause was controlled. Women with low body mass indices (BMIs) had significantly lower BMC than women with average or greater than average BMIs. More active women had higher BMC than less active women at both appendicular and axial sites. A trend suggesting that women with higher calcium intake may have higher BMC was statistically significant only at the midradial site. A trend of postmenopausal women having lower BMC than pre- or perimenopausal women was also statistically significant only at the midradial site. Only modest correlations were found between the various sites. These correlations are too weak to allow accurate clinical predictions of BMC at axial sites from the BMC at an appendicular site in individual patients.