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Updated: Jun 15, 2026
07:52
Conjunctival Commensal Isolation and Identification in Mice
Published on: May 1, 2021
Pathogenesis of contact lens-associated microbial keratitis
Suzanne M J Fleiszig1, David J Evans
1School of Optometry and Graduate Programs in Vision Science, Microbiology, Infectious Disease and Immunity, and Health and Medical Sciences, University of California-Berkeley, Berkeley, CA, USA. fleiszig@berkeley.edu
Summary
Microbial keratitis from contact lens wear is a persistent problem despite advances in lens technology. This perspective reviews the disease
Area of Science:
- Ophthalmology
- Microbiology
- Infectious Diseases
Background:
- Contact lens-related microbial keratitis is a significant cause of sight-threatening infections.
- Despite technological advancements in contact lenses and solutions, disease incidence has not decreased.
- Understanding the complex pathogenesis is crucial for effective prevention and treatment.
Purpose of the Study:
- To provide a perspective on the complex pathogenesis of microbial keratitis.
- To identify factors hindering a comprehensive understanding of the disease.
- To discuss novel approaches for addressing this clinical challenge.
Main Methods:
- Literature review and synthesis of existing research.
- Analysis of factors contributing to disease incidence.
- Discussion of emerging strategies and technologies.
Main Results:
- The pathogenesis of microbial keratitis is multifactorial and not fully understood.
- Technological improvements have not significantly reduced infection rates.
- New research directions are exploring innovative solutions.
Conclusions:
- Microbial keratitis remains a critical issue in contact lens wear.
- A deeper understanding of pathogenesis is needed to improve patient outcomes.
- Continued research into novel prevention and treatment strategies is essential.
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