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Updated: Jun 15, 2026

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

Induced G1 cell-cycle arrest controls replication-dependent histone mRNA 3' end processing through p21, NPAT and CDK9

J Pirngruber1, S A Johnsen

  • 1Department of Molecular Oncology, Göttingen Center for Molecular Biosciences, University of Göttingen, Göttingen, Germany.

Oncogene
|March 2, 2010
PubMed
Summary

p53-induced cell cycle arrest reduces histone gene transcription by decreasing Nuclear Protein, Ataxia-Telangiectasia Locus (NPAT) levels. This alters mRNA processing, switching to polyadenylation and impacting DNA packaging during cell division.

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