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PTH battles TGF-beta in bone
1NSERM UMRS 938, Hôpital St-Antoine, 184 Rue du Faubourg St-Antoine, 75571, Paris, France. azeddine.atfi@inserm.fr
Nature Cell Biology
|March 2, 2010
Abstract:
Bone remodelling in vertebrates is coordinately regulated by the opposing effects of parathyroid hormone (PTH) and transforming growth factor-beta (TGF-beta). PTH couples the processes of bone resorption and formation by enforcing simultaneous internalization of TGF-beta type II receptor (TbetaRII) and PTH type 1 receptor (PTH1R), which attenuates both TGF-beta and PTH signalling in vivo.
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