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Updated: Jun 15, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
An efficient synthesis of the tamandarin B macrocycle
Kenneth M Lassen1, Jisun Lee, Madeleine M Joullié
1Department of Chemistry, University of Pennsylvania, 231 S. 34 Street, Philadelphia, PA 19104 USA.
A new cyclization protocol efficiently produces the tamandarin B macrocycle. This method aids in creating related compounds for further research.
Area of Science:
- Organic Chemistry
- Medicinal Chemistry
Background:
- Tamandarin B is a complex natural product with potential biological activity.
- Efficient synthesis of macrocyclic compounds is crucial for drug discovery.
Purpose of the Study:
- To develop a reliable and high-yielding cyclization protocol for the tamandarin B macrocycle.
- To enable the synthesis of side chain analogues of tamandarin B.
Main Methods:
- A novel cyclization strategy was employed.
- Optimization of reaction conditions for macrocyclization.
Main Results:
- Achieved a reliable and high-yielding macrocyclization of tamandarin B.
- Demonstrated the protocol's effectiveness for synthesizing analogues.
Conclusions:
- The presented cyclization protocol is a valuable tool for tamandarin B synthesis.
- This work facilitates the exploration of tamandarin B derivatives and their potential applications.
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