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Risk factors for periventricular-intraventricular hemorrhage in premature infants

Ju Young Lee1, Han Suk Kim, Euiseok Jung

  • 1Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.

Journal of Korean Medical Science
|March 2, 2010
PubMed

Insights

Periventricular-intraventricular hemorrhage (PV-IVH) in preterm infants is linked to metabolic acidosis and inotrope use. Maternal antenatal corticosteroid use was found to decrease the risk of PV-IVH.

Area of Science:

  • Neonatal Neurology
  • Perinatal Medicine
  • Pediatric Critical Care

Background:

  • Periventricular-intraventricular hemorrhage (PV-IVH) is a significant cause of neurological impairment in premature infants.
  • Identifying perinatal risk factors is crucial for preventing PV-IVH.

Purpose of the Study:

  • To investigate perinatal factors associated with the occurrence of PV-IVH in preterm newborns.
  • To determine risk and protective factors for PV-IVH.

Main Methods:

  • Retrospective case-control study of preterm infants (< or =34 weeks gestation) admitted to Seoul National University Children's Hospital and Seoul National University Bundang Hospital (June 2003-December 2007).
  • Cases: 59 infants with PV-IVH (grade 2-4). Controls: 118 infants without PV-IVH, matched for gestational age and birth weight.
  • Multivariate logistic regression analysis was used to identify associated factors.

Main Results:

  • Metabolic acidosis (OR: 6.94; 95% CI: 1.12-43.23) and the use of inotropes (OR: 3.70; 95% CI: 1.16-11.84) were significantly associated with an increased risk of PV-IVH.
  • Maternal use of antenatal corticosteroids demonstrated a protective effect, decreasing the risk of PV-IVH (OR: 0.36; 95% CI: 0.14-0.92).

Conclusions:

  • Metabolic acidosis and inotrope administration are identified as significant risk factors for PV-IVH in preterm infants.
  • Antenatal corticosteroid administration to mothers is a protective factor against PV-IVH, highlighting its importance in perinatal care.

Keywords:
Infant, PrematureIntensive Care, NeonatalIntracranial HemorrhagesRisk Factors

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