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Aloe-induced toxic hepatitis.

Ha Na Yang1, Dong Joon Kim, Young Mook Kim

  • 1Department of Internal Medicine, College of Medicine, Hallym University, Chuncheon, Korea.

Journal of Korean Medical Science
|March 2, 2010
PubMed
Summary

Aloe vera, used in phytomedicine for its beneficial effects, can cause toxic hepatitis. Three women developed liver injury after consuming aloe preparations, with symptoms resolving upon discontinuation.

Keywords:
AloeHepatitis, Toxic

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Area of Science:

  • Herbal medicine
  • Hepatology
  • Toxicology

Background:

  • Aloe vera is a widely used phytomedicine with reported anti-inflammatory, anti-proliferative, and anti-aging properties.
  • Despite its common use, the pharmacokinetics and toxicity of aloe vera are not well-documented in scientific literature.
  • Recent reports have indicated potential cases of aloe-induced hepatotoxicity.

Observation:

  • Three female patients (ages 57, 62, and 55) presented with acute hepatitis.
  • All patients had been consuming oral aloe preparations for several months prior to admission.
  • Clinical, laboratory, and histological findings met the diagnostic criteria for toxic hepatitis using the Roussel Uclaf Causality Assessment Method (RUCAM) scale.

Findings:

  • The presented cases strongly suggest a causal link between oral aloe vera consumption and the development of toxic hepatitis.
  • Discontinuation of the aloe preparations led to the normalization of liver enzymes in all affected patients.
  • Histological examination confirmed liver injury consistent with drug-induced liver injury.

Implications:

  • Aloe vera should be recognized as a potential causative agent for drug-induced liver injury and hepatotoxicity.
  • Healthcare providers should consider aloe vera as a potential cause when evaluating patients with unexplained hepatitis.
  • Further research into the specific compounds and mechanisms responsible for aloe-induced hepatotoxicity is warranted.