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Peripheral ulcerative keratitis associated with hideradenitis suppurativa
M A Mahmood1, S Pillai, S R Limaye
1Ophthalmology Service, D.C. General Hospital, Washington, D.C. 20003.
Cornea
|January 1, 1991
Summary
Peripheral ulcerative keratitis (PUK), an eye condition, can be linked to hidradenitis suppurativa (HS). This case study shows HS-associated PUK responded to cyclophosphamide treatment.
Area of Science:
- Ophthalmology
- Dermatology
- Rheumatology
Background:
- Peripheral ulcerative keratitis (PUK) is a serious noninfectious corneal inflammation.
- PUK can be idiopathic (Mooren's ulcer) or associated with systemic diseases, notably collagen vascular disorders.
Observation:
- A patient presented with bilateral peripheral infiltrative and ulcerative keratitis.
- This keratitis was associated with severe hidradenitis suppurativa (HS), a chronic skin condition affecting apocrine glands.
Findings:
- The patient's PUK was refractory to standard treatments.
- Successful treatment was achieved with oral immunosuppression using cyclophosphamide.
Implications:
- This case highlights a rare association between hidradenitis suppurativa and peripheral ulcerative keratitis.
- Immunosuppression with cyclophosphamide may be a viable treatment option for severe, refractory HS-associated PUK.