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Related Concept Videos

Embryonic Connective Tissues01:20

Embryonic Connective Tissues

During early development, the embryo forms two types of connective tissues— the mesenchyme and mucoid connective tissue.
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development. Mesenchyme is...

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Loss-of-Function Approach in the Embryonic Chick Retina by Using Tol2 Transposon-Mediated Transgenic Expression of Artificial microRNAs
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Tie2 expression in human embryonic tissues.

Simona Sârb1, Anca Maria Cîmpean, D Grigoraş

  • 1Department of Histology, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania. simona_sarb@yahoo.com

Romanian Journal of Morphology and Embryology = Revue Roumaine De Morphologie Et Embryologie
|March 2, 2010
PubMed
Summary

Tie2 receptor tyrosine kinase is crucial for blood vessel formation and stabilization during early human embryo development. Its expression patterns reveal key processes in vasculogenesis and angiogenesis in developing human embryos.

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Isolation of Murine Valve Endothelial Cells
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Published on: August 21, 2014

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Last Updated: Jun 15, 2026

Loss-of-Function Approach in the Embryonic Chick Retina by Using Tol2 Transposon-Mediated Transgenic Expression of Artificial microRNAs
06:58

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Published on: May 18, 2022

Isolation of Murine Valve Endothelial Cells
09:34

Isolation of Murine Valve Endothelial Cells

Published on: August 21, 2014

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Vascular Biology

Background:

  • Tie2 is a receptor tyrosine kinase vital for blood vessel development.
  • It plays a role in vasculogenesis, angiogenesis, and maintaining vascular integrity.
  • Tie2 function is critical during embryonic development, wound healing, and tumor growth.

Purpose of the Study:

  • To investigate Tie2 expression in human embryos during early development.
  • To correlate Tie2 expression with stages of vasculogenesis and angiogenesis.
  • To understand the role of Tie2 in blood vessel maturation and stabilization.

Main Methods:

  • Immunohistochemical analysis of Tie2 expression.
  • Examination of human embryonic tissues at 5 and 7 weeks of development.
  • Microscopic evaluation of Tie2 localization and intensity.

Main Results:

  • Tie2 expression was detected in vascular cords within mesenchymal tissue.
  • Maximum Tie2 intensity was observed in the connective tissue near the primitive spinal cord.
  • In 7-week embryos, Tie2 was negative in large vessels but heterogeneous in those with bridging.

Conclusions:

  • Tie2 is actively expressed during early human embryonic development (5-7 weeks).
  • Concurrent vasculogenesis, angiogenesis, and blood vessel stabilization occur during this period.
  • Tie2 expression patterns indicate its role in vascular development and maturation.