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Published on: October 23, 2012
[Cyanoacrylate adhesives for the synthesis of soft tissue]
Sybele Saska1, Ana Maria Minarelli Gaspar, Eduardo Hochuli-Vieira
1Instituto de Química de Araraquara, Universidade Estadual Paulista, São Paulo, SP, Brasil. sybele_saska@yahoo.com.br
Background:
Tissue adhesives have been used for the synthesis of wound due to their painless application and quick and easy handling.
Objectives:
The purpose of this study was to analyze and compare the compatibility of the adhesives ethylcyanoacrylate (Super Bonder) and butyl-cyanoacrylate (Histoacryl), and to compare the reparation of incisions in the dorsum of rats with suture and the respective adhesives.
Methods:
Fifteen rats were used. Two surgical pockets were created in their dorsum. A polyethylene tube (10mm x 1mm) was implanted in each one. Each tube was filled with the adhesives Super Bonder(left side) and Histoacryl (right side). The incisions on the left side were closed with Super Bonder, and the incisions on the right side, with Histoacryl. A median incision between the two other incisions was made and closed with braided silk suture. The animals were killed after, 7, 35 and 120 days.
Results:
The adhesives used in the present study did not promote inflammatory reaction when used for the synthesis of incisions. However, when implanted subcutaneously, they caused an inflammatory reaction within 120 days. Reaction is more severe with Histoacryl.
Conclusions:
Super Bonder and Histoacryl can be used effectively in the healing of incised tissues; they aid in the suture of incisions. However, these adhesives can be used for the synthesis of wounds, lacerations or cutaneous incisions.
