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High-Throughput Small Molecule Drug Screening For Age-Related Sleep Disorders Using Drosophila melanogaster

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Sleep disorders in aging and dementia.

S Bombois¹, P Derambure, F Pasquier

¹Center for Memory Resources and Research, EA2691, Lille University Hospital, University of Lille Nord de France, Lille cedex, France. stephanie.bombois@chru-lille.fr

The Journal of Nutrition, Health & Aging

|March 2, 2010

Summary

This summary is machine-generated.

Sleep disorders are common in older adults and those with cognitive impairment, increasing dementia risk and mortality. Early characterization and treatment of sleep issues are crucial for managing dementia and supporting caregivers.

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Multi-Modal Home Sleep Monitoring in Older Adults

Multi-Modal Home Sleep Monitoring in Older Adults

Published on: January 26, 2019

Area of Science:

Gerontology
Neurology
Sleep Medicine

Background:

Sleep disturbances and circadian rhythm modifications are more frequent in aging populations.
While many older adults report poor sleep, true sleep disorders are less common and often linked to comorbidities.
Sleep disorders in Alzheimer's disease (AD) patients mirror those in non-demented elderly but are more severe.

Purpose of the Study:

To review sleep disorder characteristics in individuals at higher risk for dementia: elderly adults, mild cognitive impairment (MCI) patients, and those with neurodegenerative diseases.
To explore the relationship between sleep disorders and dementia progression, including potential predictive roles.
To consider treatment guidelines for sleep disorders in elderly and demented populations.

Main Methods:

Literature review of sleep disorders in at-risk populations.
Analysis of prevalence and characteristics of primary sleep disorders (e.g., REM sleep behavior disorder, sleep apnea) in aging and neurodegenerative conditions.
Consideration of diagnostic approaches, including polysomnography.

Main Results:

Prevalence of sleep disorders like Rapid Eye Movement (REM) sleep behavior disorders (RBDs) and sleep apnea increases with age and in neurodegenerative diseases.
RBDs are indicative of Lewy body dementia and predict neurodegeneration in Parkinson's disease.
Obstructive sleep apnea (OSA) shares risk factors with AD and may be implicated in its pathology.

Conclusions:

Poor sleep significantly increases morbidity and mortality in demented patients and stresses caregivers.
Sleep disorders may be early predictors of dementia progression or symptoms of undiagnosed sleep issues in MCI.
Thorough sleep characterization, using standardized interviews and polysomnography, is recommended for frail elderly and early-stage AD patients.