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Related Experiment Video

Updated: Jun 15, 2026

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

Cancer preceding giant cell arteritis: a case-control study.

Tanaz A Kermani¹, Valentin S Schäfer, Cynthia S Crowson

¹Mayo Clinic, Rochester, Minnesota 55905, USA. kermani.tanaz@mayo.edu

Arthritis and Rheumatism

|March 2, 2010

Summary

This summary is machine-generated.

Giant cell arteritis (GCA) patients had fewer previous cancers than controls. This population-based study suggests a potential inverse association between prior malignancy and GCA risk.

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Area of Science:

Epidemiology
Rheumatology
Oncology

Background:

Giant cell arteritis (GCA) is a systemic vasculitis primarily affecting large arteries.
The potential association between GCA and prior cancer history remains an area of investigation.

Purpose of the Study:

To investigate the relationship between a history of cancer and the occurrence of giant cell arteritis.
To determine if prior malignancies influence the risk of developing GCA.

Main Methods:

A population-based case-control study utilizing the Rochester Epidemiology Project.
Incident GCA cases (diagnosed 1950-2004) were matched to controls without GCA.
Medical records were reviewed, and cancer diagnoses were histopathologically confirmed.

Main Results:

The study included 204 GCA cases and 407 controls.
Significantly fewer GCA patients (22%) had a history of cancer compared to controls (31%) (OR 0.63, P=0.022).
No significant differences in age at cancer diagnosis or time from cancer to index date were observed between groups.

Conclusions:

GCA patients demonstrated a significantly lower prevalence of prior malignancies compared to controls.
These findings suggest a potential inverse association between previous cancer and the development of GCA.