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Related Experiment Video

Updated: Jun 15, 2026

Technical Aspects of the Mouse Aortocaval Fistula

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Published on: July 11, 2013

Angiosarcoma developing in a non-functioning arteriovenous fistula post-renal transplant.

Yassar A Qureshi¹, Dirk C Strauss, Khin Thway

¹The Royal Marsden Hospital, Soft Tissue Sarcoma Unit, London, UK. yassarqureshi@hotmail.co.uk

Journal of Surgical Oncology

|March 2, 2010

Summary

Angiosarcomas are rare vascular tumors. This case highlights their potential development in arteriovenous fistulae of post-renal transplant patients, emphasizing the need for vigilance.

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Area of Science:

Oncology
Vascular Surgery
Transplant Surgery

Background:

Angiosarcomas are rare endothelial cell sarcomas, accounting for less than 1% of all sarcomas.
Chronic immunosuppression is a known risk factor for various malignancies.
A link between immunosuppression and angiosarcoma development is established, with rare cases reported post-renal transplant.

Observation:

This report details a case of angiosarcoma arising in a ligated native arteriovenous (AV) fistula.
The patient was a 48-year-old male with a history of successful ABO-incompatible renal transplant.
The angiosarcoma developed in the background of post-transplant immunosuppression.

Findings:

Six cases of angiosarcoma in AV fistulae among post-renal transplant patients have been previously reported.
This case adds to the literature, presenting another instance of angiosarcoma in this specific patient population.
The study reviews literature to explore potential mechanisms for angiosarcoma development in post-transplant patients.

Implications:

Angiosarcomas are rare but should be considered in the differential diagnosis of evolving masses near AV fistulae.
Diagnosis requires a high index of suspicion and confirmation through histological examination.
Clinicians and patients must be aware that any evolving mass in or around an AV fistula warrants urgent biopsy.