Related Experiment Video

Updated: Jun 15, 2026

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis
05:56

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Published on: August 29, 2025

[Evaluation of quality of life in children with chronic hepatitis]

Alice Nicoleta Azoicăi1, Evelina Moraru, Doina Azoicăi

  • 1Clinica a II-a Pediatrie, Facultatea de Medicină, Spitalul Clinic de Pediatrie "Sf. Maria" Iaşi, Universitatea de Medicină si Farmacie "Gr.T. Popa" Iaşi.

Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi
|March 3, 2010
PubMed

Insights

Children with chronic hepatitis perceive their disease positively, likely due to young age and low liver dysfunction rates. Quality of life studies effectively evaluate treatment efficacy in pediatric chronic liver disease.

Area of Science:

  • Pediatric Hepatology
  • Clinical Research Methodology
  • Quality of Life Assessment

Context:

  • Chronic liver diseases, including viral and autoimmune hepatitis, significantly impact children's quality of life and family well-being.
  • Assessing quality of life is crucial for understanding the patient experience and treatment outcomes in pediatric hepatology.
  • This study focuses on children hospitalized with chronic liver conditions at a specialized pediatric hospital.

Purpose:

  • To analyze the quality of life in children and adolescents diagnosed with chronic liver disease.
  • To evaluate the applicability and utility of a specific questionnaire (Kindle questionnaire) for assessing quality of life in this pediatric population.
  • To explore the relationship between disease perception, age, and liver function in children with chronic hepatitis.

Summary:

  • A study involving 45 pediatric patients with chronic viral or autoimmune hepatitis utilized the Kindle questionnaire to assess quality of life.
  • Results indicated a generally positive perception of the disease among young patients (under 17) with minimal liver dysfunction.
  • The questionnaire demonstrated good applicability, being simple and easy for children to complete.

Impact:

  • Quality of life assessments provide valuable insights into the effectiveness of therapeutic interventions for chronic liver disease in children.
  • Findings suggest that age and disease severity are key factors influencing a child's perception of their chronic condition.
  • This research supports the integration of quality of life measures into routine clinical practice for evaluating treatment success in pediatric liver disease.
Abstract

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug binding...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...