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Updated: Jun 15, 2026

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Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
Published on: August 1, 2018
[Frozen section exam value in breast cancer]
1Universitatea de Medicină si Farmacie "Gr.T. Popa" Iaşi. Facultatea de Medicină, Clinica a III-a Chirurgie, Spitalul Clinic Judeţean de Urgenţă "Sf. Spiridon" Iaşi.
Summary
Frozen section examination provides rapid histopathological diagnosis during surgery, guiding treatment decisions. Its role has evolved to focus on sentinel lymph node evaluation and margin assessment, improving patient care.
Area of Science:
- Pathology
- Surgical Oncology
Context:
- Frozen section examination offers immediate histopathological diagnosis, influencing surgical extent.
- Advances in screening and preoperative diagnosis have shifted the role of frozen section analysis.
- Current applications focus on sentinel lymph node metastasis and specimen margin evaluation.
Purpose:
- To highlight the evolving role of frozen section examination in surgical pathology.
- To discuss its application in sentinel lymph node biopsy and margin assessment.
Summary:
- Frozen section examination, initially for intraoperative diagnosis, now aids in evaluating sentinel lymph node metastasis and surgical margins.
- This technique is crucial for conservative treatments and influences therapeutic decisions.
- Its indications are expanding with continuous improvements.
Impact:
- Enhanced intraoperative decision-making in surgical procedures.
- Improved accuracy in staging and treatment planning for various cancers.
- Facilitates minimally invasive techniques like sentinel lymph node biopsy.
