[Thermal stability evaluation of some W/O/W double emulsions containing 1% piroxicam by rheological measurements]
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Published on: June 6, 2017
Lavinia Vlaia1, V Vlaia, Ioana Olariu
1Facultatea de Farmacie, Disciplina de Tehnologie Farmaceutică, Universitatea de Medicină si Farmacie "Victor Babeă" Timişoara.
Unlabelled:
The aim of this work was to evaluate thermal stability of some W/O/W concentrated double emulsions (with 80% dispersed phase) containing 1% piroxicam following their theological behaviour at various temperatures. W/O/W double emulsions containing 1% piroxicam were prepared using the two-step procedure.
Results:
The variable parameter of formulations was the hydrophilic macromolecule compound dispersed in the internal and external aqueous phases (hydroxyethylcellulose and Carbopol 940). Rheological behaviour and viscosity of the obtained W/O/W double emulsions was measured at 15 degrees C, 20 degrees C, 25 degrees C, 30 degrees C and 35 degrees C respectively, after preparation. The obtained results demonstrated that the studied W1/O/W2 double emulsions containing 1% piroxicam were stable under applied thermal stress, although they exhibited some differences in rheological properties caused by formulation variable.
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