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Related Concept Videos

Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
Bias in Epidemiological Studies01:29

Bias in Epidemiological Studies

Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is:
Hypodermis01:02

Hypodermis

The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...

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Updated: Jun 15, 2026

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

[Obesity paradox].

Viviana Aursulesei1, A Cozma, M D Datcu

  • 1Facultatea de Medicină, Clinica I Medicală Cardiologică, Universitatea de Medicină si Farmacie "Gr.T. Popa" Iaşi.

Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi
|March 3, 2010
PubMed
Summary
This summary is machine-generated.

Obesity is linked to cardiovascular issues, yet overweight individuals with existing heart disease often have better outcomes. This review explores the "obesity paradox" and its potential explanations, highlighting ongoing research.

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Multidisciplinary Approach to Obesity Management: A Case Report
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Area of Science:

  • Metabolic and vascular consequences of obesity.
  • Pathological effects of obesity on cardiovascular system.

Context:

  • Obesity is a global epidemic linked to cardiovascular diseases and reduced survival.
  • The obesity paradox suggests better prognosis for overweight/obese patients with cardiovascular disease.

Purpose:

  • To review metabolic and vascular consequences of dysfunctional adipocytokines in obesity.
  • To examine pathological effects on blood pressure, cardiovascular structure, and function.
  • To explore explanations for the obesity paradox in cardiovascular disease.

Summary:

  • Dysfunctional adipocytokines in obesity contribute to metabolic and vascular issues, impacting cardiovascular health.
  • The obesity paradox, where overweight/obese individuals with cardiovascular disease show better prognosis, is explored.
  • Potential explanations for the paradox include lower systemic vascular resistance in hypertension and metabolic reserve in heart failure.

Impact:

  • Provides insights into the complex relationship between obesity and cardiovascular disease prognosis.
  • Highlights the need for further research into the mechanisms underlying the obesity paradox.
  • Informs clinical perspectives on weight management in cardiovascular disease prevention and treatment.