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Updated: Jun 15, 2026

Murine Model of Advanced Periodontitis Induced by Nylon Ligature in the Second Upper Molar
Published on: May 30, 2025
[The bony modifications in the periodontal pockets]
R M Vataman1, C Cotuţiu, St Lăcătuşu
1Facultatea de Medicină Dentară, Clinica de Odontologie si Parodontologie, Universitatea de Medicină si Farmacie "Gr.T. Popa" Iaşi.
Unlabelled:
The aim of this study was to demonstrate the bony structural changes in deep periodontal pockets.
Material And Methods:
Bony fragments were taken from the alveolar wall of a group of 24 patients diagnosed with deep periodontal lesions which required the extraction of certain irrecuperable teeth. Fragments were fixed in glutaraldehyde, then decalcified in EDTA 5% and proccesed for electron microscopic examination and a semifinesse sections to microscop "Zeiss Axioscop".
Results:
Both optic and electron microscopy showed: decreaze of bone mineralization and alterations in cholagen structure; the presence of osteoclasts with intense activity and numerous macrofages; at the level of bone marrow, small, insignificant inflammatory reactions, contrasting with the important surrounding modifications; in certain cases though osteolytic reactions occured, the osteoclasts could not by evidenced, on the contrary, numerous macrophages with intense lysosomal enzymes activity were noticed; all the cases showed an alteration of the alveolar bone cholagen.
Conclusion:
Thus, we can better understand the role of primary factors in this bony structures.
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