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Updated: Jun 15, 2026

Laser-induced Breakdown Spectroscopy: A New Approach for Nanoparticle's Mapping and Quantification in Organ Tissue
Published on: June 18, 2014
Note: Application of laser produced plasma K alpha x-ray probe in radiation biology
Masaharu Nishikino1, Katsutoshi Sato, Noboru Hasegawa
1Quantum Beam Science Directorate, Japan Atomic Energy Agency, Advanced Photon Research Center, 8-1-7 Umemidai, Kizugawa, Kyoto 619-0215, Japan. nishikino.masaharu@jaea.go.jp
Abstract:
A dedicated radiation biology x-ray generation and exposure system has been developed. 8.0 keV in energy x-ray pulses generated with a femtosecond-laser pulse was used to irradiate sample cells through a custom-made culture dish with a silicon nitride membrane. The x-ray irradiation resulted in DNA double-strand breaks in the nucleus of a culture cell that were similar to those obtained with a conventional x-ray source, thus demonstrating the feasibility of radiobiological studies utilizing a single burst of x-rays focused on single cell specimens.
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