Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fibril-associated Collagen01:11

Fibril-associated Collagen

Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
Fibronectins Connect Cells with ECM01:25

Fibronectins Connect Cells with ECM

Fibronectin is an adhesive glycoprotein present in the extracellular matrix of embryogenic and adult tissue. These molecules primarily aid in regulating cell motility and attachment. A fibronectin molecule is composed of two identical polypeptide chains attached to each other by a pair of disulfide bonds at the C-terminal.
Both proteoglycans and collagen are attached to fibronectin proteins, which, in turn, are attached to integrin proteins. These integrin proteins interact with transmembrane...
Fibrous Proteins00:55

Fibrous Proteins

Fibrous proteins are either long and narrow proteins or assemble to form long and thin structures. They contain repetitive units and usually consist of either alpha helices or beta sheets and, in rare cases, a mix of both. The amino acids in the primary structure often consist of repeating amino acid sequences. The role of fibrous proteins is primarily structural. Many are located in the extracellular matrix and are present in connective tissues to impart strength and joint mobility. They are...
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
Type IV Collagen of Basal Lamina01:05

Type IV Collagen of Basal Lamina

Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
A type IV collagen molecule has six alpha chains which can exist in...
Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Carbon Ion Fluxes at Mars: First Results of Tailward Flows From MAVEN-STATIC.

Journal of geophysical research. Space physics·2022
Same author

In Situ Measurements of Thermal Ion Temperature in the Martian Ionosphere.

Journal of geophysical research. Space physics·2022
Same author

Synergistic multiple early therapy (SMET) for inflammatory diseases with pathogenic autoinflammatory feedback circuits.

The British journal of dermatology·2021
Same author

Identifying Ultra Low Frequency Waves in the Lunar Plasma Environment Using Trajectory Analysisand Resonance Conditions.

Journal of geophysical research. Space physics·2021
Same author

Solar Wind and Interplanetary Magnetic Field Influence on Ultralow Frequency Waves and Reflected Ions Near the Moon.

Journal of geophysical research. Space physics·2021
Same author

A Tenuous Lunar Ionosphere in the Geomagnetic Tail.

Geophysical research letters·2021

Related Experiment Video

Updated: Jun 15, 2026

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
08:09

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Published on: March 24, 2017

Psoriasis and extra domain A fibronectin loops.

J P McFadden1, B S Baker, A V Powles

  • 1Department of Cutaneous Allergy, St John's Institute of Dermatology, St Thomas' Hospital, London SE1 7EH, UK. john.mcfadden@kcl.ac.uk

The British Journal of Dermatology
|March 3, 2010
PubMed
Summary

The transforming growth factor-beta/fibronectin (FN)/alpha5beta1 pathway, particularly EDA+ FN, drives psoriasis by stimulating keratinocyte proliferation and inflammation. These "FN loops" maintain lesions and may link psoriasis to heart disease.

Related Experiment Videos

Last Updated: Jun 15, 2026

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
08:09

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Published on: March 24, 2017

Area of Science:

  • Immunodermatology
  • Molecular Biology
  • Pathophysiology

Background:

  • Psoriasis pathogenesis involves T-helper (Th) 1 and Th17 cells.
  • The transforming growth factor (TGF)-beta/fibronectin (FN)/alpha5beta1 pathway is implicated in psoriasis.
  • EDA+ FN, an alternatively spliced FN isoform, stimulates keratinocyte hyperproliferation and pro-inflammatory cytokine production via Toll-like receptor (TLR) 4.

Purpose of the Study:

  • To elucidate the role of the TGF-beta/FN/alpha5beta1 pathway in psoriasis.
  • To investigate the mechanisms of EDA+ FN production and its feedback loops in psoriatic lesions.
  • To explore potential links between EDA+ FN and cardiovascular complications in psoriasis.

Main Methods:

  • The study is primarily based on existing literature and postulated mechanisms.
  • Analysis of the molecular interactions between TGF-beta, EDA+ FN, keratinocytes, and immune cells.
  • Review of evidence linking fibronectin and inflammation.

Main Results:

  • EDA+ FN production is induced by TGF-beta and sustained by autocrine keratinocyte proliferation.
  • EDA+ FN stimulates TLR4 on antigen-presenting cells, leading to pro-inflammatory cytokine release (TNF-alpha, IL-1, IL-6, IL-12).
  • Th1 cells recruited to lesions also produce EDA+ FN, creating positive feedback loops ('FN loops').

Conclusions:

  • The proposed 'FN loops' involving EDA+ FN contribute to the maintenance and progression of psoriatic lesions.
  • EDA+ FN may represent a therapeutic target for psoriasis.
  • EDA+ FN's pro-atherosclerotic properties suggest a potential mechanism linking psoriasis to heart and thrombotic diseases.