Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Antigen Presenting Cells

Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...

Cells of the Adaptive Immune Response

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...

Primary Lymphoid Organs

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...

T Cell Activation and Clonal Selection

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

Development of the Lymphatic System

Development of the Lymphatic System

The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...

Diversity of Antigen Receptors

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Correction: Overexpression of TopBP1, a canonical ATR/Chk1 activator, paradoxically hinders ATR/Chk1 activation in cancer.

The Journal of biological chemistry·2021

Same author

Comprehensive analysis of DNA methylation and gene expression profiles in gestational diabetes mellitus.

Medicine·2021

Same author

Characterization of chondroitin sulfates isolated from large hybrid sturgeon cartilage and their gastroprotective activity against ethanol-induced gastric ulcers.

Food chemistry·2021

Same author

Inhibition of inducible nitric oxide synthase improved erectile dysfunction in rats with type 1 diabetes.

Andrologia·2021

Same author

Five metastasis-related mRNAs signature predicting the survival of patients with liver hepatocellular carcinoma.

BMC cancer·2021

Same author

Exosomes from miRNA-378-modified adipose-derived stem cells prevent glucocorticoid-induced osteonecrosis of the femoral head by enhancing angiogenesis and osteogenesis via targeting miR-378 negatively regulated suppressor of fused (Sufu).

Stem cell research & therapy·2021

Search research articles

Related Experiment Video

Updated: Jun 15, 2026

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

Origin and development of dendritic cells.

Kang Liu¹, Michel C Nussenzweig

¹Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA. liuk@rockefeller.edu

Immunological Reviews

|March 3, 2010

Summary

Dendritic cells (DCs), crucial for immunity, develop from a common progenitor and differentiate into distinct subtypes. Their tissue distribution, function, and homeostasis are regulated by Flt3L.

Area of Science:

Immunology
Cell Biology

Background:

Dendritic cells (DCs) are key antigen-presenting cells vital for immune responses and tolerance.
DCs exhibit heterogeneity in markers, location, and function.
Understanding DC development and function is critical for immunology.

Purpose of the Study:

To review the development and function of dendritic cells in lymphoid and non-lymphoid tissues.
To elucidate the origins and differentiation pathways of DCs.
To highlight the regulatory mechanisms governing DC homeostasis.

Main Methods:

Review of existing literature on dendritic cell development and function.
Analysis of cell lineage origins from monocyte and dendritic cell progenitors (MDPs).
Examination of pre-DC migration and differentiation into tissue-specific DC subsets.

More Related Videos

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro

Published on: March 7, 2022

Economical and Efficient Protocol for Isolating and Culturing Bone Marrow-derived Dendritic Cells from Mice

Economical and Efficient Protocol for Isolating and Culturing Bone Marrow-derived Dendritic Cells from Mice

Published on: July 1, 2022

Related Experiment Videos

Last Updated: Jun 15, 2026

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro

Published on: March 7, 2022

Economical and Efficient Protocol for Isolating and Culturing Bone Marrow-derived Dendritic Cells from Mice

Economical and Efficient Protocol for Isolating and Culturing Bone Marrow-derived Dendritic Cells from Mice

Published on: July 1, 2022

Main Results:

DC and monocyte lineages arise from a common monocyte and dendritic cell progenitor (MDP).
Committed DC progenitors (CDPs) differentiate into pre-DCs, which migrate to various tissues.
Two major DC subpopulations, lymphoid tissue DCs and non-lymphoid tissue CD103(+) DCs, are identified.
Flt3L hormone regulates DC division and homeostasis within tissues.

Conclusions:

DCs originate from a common progenitor with monocytes, diverging into distinct lineages.
Tissue-specific DC subsets develop from pre-DC precursors.
Flt3L is a key regulator of dendritic cell development and tissue maintenance.