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T Cell Activation and Clonal Selection

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...

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An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

Published on: April 18, 2016

Defining dendritic cells by conditional and constitutive cell ablation.

Liat Bar-On¹, Steffen Jung

¹Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel.

Immunological Reviews

|March 3, 2010

Summary

Recent studies advance understanding of dendritic cell (DC) organization, revealing their origins and functions. This review focuses on classical DC functions in mice, distinguishing them from macrophages.

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Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

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Published on: May 18, 2018

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Last Updated: Jun 15, 2026

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

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Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro

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Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

Area of Science:

Immunology
Cell Biology

Background:

Significant progress has been made in understanding the dendritic cell (DC) compartment.
Studies on DC origins, transcription factors, and growth factor requirements have been particularly insightful.
Adoptive cell transfers have demonstrated precursor/progeny relationships within the DC compartment.

Purpose of the Study:

To provide functional definitions for DC subsets.
To reveal potential task divisions distinguishing DCs from other immune cells, including macrophages.
To review recent insights into the functions of classical DCs in mice.

Main Methods:

Review of recent scientific literature.
Focus on studies involving conditional and constitutive cell ablation in mice.
Analysis of transcription factor and growth factor requirements for DC development.

Main Results:

Advancements in understanding DC origins and precursor/progeny relationships.
Highlighting the need for functional definitions to differentiate DCs from macrophages.
Focus on the functions of classical DCs in mouse models.

Conclusions:

Functional definitions are crucial for fully understanding the DC compartment.
Functional distinctions may eventually supersede current classifications of DCs and macrophages.
This review consolidates current knowledge on classical DC functions in mice.