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Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro
Published on: March 7, 2022
Regulation of dendritic cell differentiation and function by Notch and Wnt pathways
Pingyan Cheng1, Jie Zhou, Dmitry Gabrilovich
1H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.
Immunological Reviews
|March 3, 2010
Summary
Notch and Wnt signaling pathways are crucial for dendritic cell development and function. Their interaction significantly impacts immune responses, offering new insights into cellular differentiation.
Area of Science:
- Immunology
- Cell Biology
- Developmental Biology
Background:
- Dendritic cell differentiation involves complex signaling networks.
- Notch and Wnt pathways are activated by interactions with bone marrow stroma.
- The specific roles of Notch and Wnt in dendritic cell development were previously unclear.
Purpose of the Study:
- To review recent findings on Notch and Wnt signaling in dendritic cell differentiation.
- To elucidate the interaction between Notch and Wnt pathways.
- To understand their impact on dendritic cell function and immune responses.
Main Methods:
- Literature review of recent studies on Notch and Wnt signaling.
- Analysis of the interplay between these pathways in hematopoietic progenitor cells.
- Examination of their role in dendritic cell differentiation and immune modulation.
Main Results:
- Notch signaling is activated by direct cell-stroma interaction.
- Wnt pathway activation is mediated by soluble stromal proteins.
- These pathways critically regulate dendritic cell differentiation and function.
Conclusions:
- Notch and Wnt signaling are essential for dendritic cell development.
- Their interaction plays a vital role in shaping immune responses.
- Further research into these pathways can inform therapeutic strategies.
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03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
03:14Notch Signaling Pathway
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
01:12Role Of Notch Signalling In Intestinal Stem Cell Renewal
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
02:54Canonical Wnt Signaling Pathway
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...