Expression and clinical significance of Ezrin and E-cadherin in esophageal squamous cell carcinoma
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Updated: Jun 15, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
Jian-Wen Zhai1, Xiao-Gang Yang, Fu-Shen Yang
1Department of Cardiothoracic Surgery, Affiliated Hospital of Hebei University of Engineering, Handan, Hebei 056002, P.R. China. zhaijw001@126.com
Background And Objective:
It has been proven that Ezrin protein may interact with E-cadherin protein and take part in metastasis of tumor cells. This study was to investigate the expressions of Ezrin and E-cadherin in esophageal squamous cell carcinoma (ESCC) and their relationship with the clinicopathologic factors, and analyze their diagnostic values for ESCC.
Methods:
The expression of Ezrin and E-cadherin in 72 specimen of ESCC and the paracancer normal squamous epithelium was detected using tissue array with SP immunohistochemistry. Their correlations to the clinicopathologic factors were analyzed statistically.
Results:
The positive rate of Ezrin was significantly higher in ESCC than in para-cancer normal squamous epithelium (90.7% vs. 46.0%, P < 0.001); the positive rate of E-cadherin was significantly lower in ESCC than in para-cancer normal squamous epithelium (27.6% vs. 97.4%, P < 0.001). Ezrin expression was related to the invasiveness and lymph node metastasis of ESCC (P < 0.05); E-cadherin expression was related to the differentiation and lymph node metastasis of ESCC (P < 0.05). The high expression of Ezrin was related to the low expression of E-cadherin (P < 0.05).
Conclusion:
The activation of Ezrin and the absence of E-cadherin contribute to the tumorigenesis and metastasis of ESCC.
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