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Age does not influence acute aspirin-induced gastric mucosal damage
J G Moore1, D J Bjorkman, M D Mitchell
1Salt Lake City Veterans Affairs Medical Center, Utah.
Gastroenterology
|June 1, 1991
Summary
Elderly and young adults show similar gastroduodenal damage from aspirin. This study found no significant age-related differences in nonsteroidal antiinflammatory drug (NSAID) induced mucosal lesions.
Area of Science:
- Gastroenterology
- Pharmacology
- Gerontology
Background:
- Elderly patients exhibit higher rates of gastroduodenal complications from NSAIDs.
- Aspirin and other NSAIDs are commonly used by both elderly and younger populations.
Purpose of the Study:
- To investigate if the gastroduodenal mucosa in elderly individuals is more susceptible to NSAID-induced damage.
- To compare NSAID-induced gastroduodenal mucosal damage between young and elderly healthy males.
Main Methods:
- Administered low (325 mg) and high (1300 mg) doses of acetylsalicylic acid to elderly and young healthy male volunteers.
- Assessed gastroduodenal mucosal damage via video-endoscopic techniques 2 hours post-dosage.
- Quantified lesions in the duodenum, gastric antrum, and gastric body by blinded endoscopists.
Main Results:
- Aspirin-induced gastroduodenal damage was dose-dependent and more pronounced in the stomach than the duodenum.
- No significant differences in the total number of gastroduodenal lesions were observed between the elderly and young age groups.
- Median gastric pH and tissue 6-ketoprostaglandin F1 alpha levels did not differ significantly between age groups.
Conclusions:
- Acute aspirin administration does not cause significantly different levels of gastroduodenal mucosal damage in elderly versus young healthy individuals.
- Age is not a significant determinant of the extent of acute aspirin-induced gastroduodenal injury.
- Findings suggest similar mucosal sensitivity to acute NSAID insult across different adult age groups.
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