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Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
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Corticotropin-releasing factor mediates the dysphoria-like state associated with alcohol withdrawal in rats

Adrie W Bruijnzeel1, Elysia Small, Tim M Pasek

  • 1Department of Psychiatry, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA. awbruijn@ufl.edu

Behavioural Brain Research
|March 3, 2010
PubMed

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Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...