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Updated: Jun 15, 2026

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
Published on: January 7, 2014
Expression analysis of suppression of tumorigenicity 13 gene in patients with Parkinson's disease
Maria I Shadrina1, Elena V Filatova, Aleksey V Karabanov
1Institute of Molecular Genetics RAS, 2 Kurchatov Sq, Moscow 123182, Russia.
Abstract:
Parkinson's disease (PD) is the second most common progressive neurodegenerative disorder characterized by the degeneration of dopaminergic neurons. Detecting changes in gene expression in untreated de novo patients with PD is important for understanding disease pathogenesis and for identifying biomarkers for preclinical stage of PD. In this study we investigate ST13 gene expression in the peripheral blood of different groups of patients with neurological diseases using reverse transcription reaction and real-time polymerase chain reaction (PCR). Our results suggest that the expression levels of ST13 cannot serve as a biomarker for early stages of PD.
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