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Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

Modulating the p53 pathway

Anwesha Dey1, David P Lane, Chandra S Verma

  • 1p53 Laboratory (A*STAR), 8A Biomedical Drive, Immunos, Singapore 138648, Singapore.

Seminars in Cancer Biology
|March 3, 2010
PubMed

Insights

The p53 protein, a key cellular protector, can be therapeutically modulated to treat diseases. Recent strategies focus on targeting p53 regulators and function for enhanced drug efficacy.

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Pharmacology

Background:

  • The p53 protein acts as a crucial transcription factor, safeguarding cells against various stressors.
  • p53 influences genes involved in cell cycle arrest, DNA repair, apoptosis, senescence, and metabolic alterations.
  • Modulating p53 activity presents a potential therapeutic avenue for diverse disease states.

Purpose of the Study:

  • To review recent advancements in modulating p53 function.
  • To outline current strategies for pharmacological intervention in the p53 pathway.
  • To highlight the development of novel animal models for studying p53 modulation.

Main Methods:

  • Strategies discussed include disrupting p53-negative regulator interactions.
  • Methods involve restabilizing mutant or misfolded p53 proteins.
  • Activation of p53-dependent transcription and systemic p53 modulation are also explored.

Main Results:

  • Pharmacological interventions targeting the p53 pathway are under investigation.
  • New approaches aim to enhance the therapeutic profiles of existing drugs by modulating p53.
  • Development of new mouse and zebrafish models facilitates in vivo research.

Conclusions:

  • Targeting the p53 pathway offers promising therapeutic strategies for various diseases.
  • Pharmacological modulation of p53 function is an active area of research.
  • Advanced animal models are crucial for validating these therapeutic developments.

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