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Multicentric Castleman disease: report of rare disease in Kuwait
B A Mohammad1, N Al-Brahim, S Kunjhibava
1Department of Medicine, Al-Farwaniya Hospital, Kuwait.
Unlabelled:
We report a rare case of multicentric Castleman disease diagnosed in Kuwait. A 56-year-old man presented with fever of unknown origin and generalized lymphadenopathy. Laboratory investigations revealed mild anemia and polyclonal gammopathy. Bone marrow biopsy demonstrated 15% increase in plasma cells. Viral screenings including HIV were negative. Lymph node biopsy showed follicular hyperplasia with inter-follicular plasma cells infiltrate with a typical morphology of plasma cell variant of Castleman disease. The patient was treated with methyl-prednisone pulse therapy and showed good response.
Conclusion:
Multicentric Castleman is a rare disease and clinicians and pathologists should be aware of it and should be considered in the differential diagnosis of fever of unknown origin and generalized lymphadenopathy.
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