Related Experiment Video
Updated: Jun 15, 2026

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries
Published on: December 27, 2016
Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and
K Kosowska-Shick1, P L McGhee, P C Appelbaum
1Department of Pathology, Hershey Medical Center, Hershey, PA 17033, USA.
Abstract:
We compared the affinities of ceftaroline for all penicillin-binding proteins (PBPs) with those of ceftriaxone and cefotaxime in 6 Staphylococcus aureus and 7 Streptococcus pneumoniae isolates with various resistance phenotypes. Ceftaroline MICs were
Related Concept Videos
Mechanism of Antibiotic Resistance in MRSA
Inhibitors of Gram-positive Cell Wall Synthesis
Factors Affecting Protein-Drug Binding: Drug-Related Factors
One crucial factor in drug-protein binding is the drug's lipophilicity or its affinity for fat. More lipophilic drugs tend to have higher binding extents. For example, highly lipophilic drugs like cloxacillin exhibit substantial protein binding, with as much as 95% of the drug binding to proteins. In contrast,...
Clinical Significance of Antibiotic Resistance
Production of Antibiotics
Combined Effects of Drugs: Synergism
Such synergistic combinations...
