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A Multimodal Wide-Field Fourier-Transform Raman Microscope

A Multimodal Wide-Field Fourier-Transform Raman Microscope

Published on: December 30, 2025

Phase-shifting point-diffraction interferometry with common-path and in-line configuration for microscopy.

Peng Gao¹, Irina Harder, Vanusch Nercissian

¹Institute of Optics, Information and Photonics, University of Erlangen, Erlangen, Germany.

|March 3, 2010

Summary

This summary is machine-generated.

A novel common-path interferometer enhances quantitative phase microscopy. This new design uses a grating pair for achromatic phase shifting, validated by experiments.

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Area of Science:

Optical microscopy
Interferometry
Phase contrast imaging

Background:

Quantitative phase microscopy (QPM) is crucial for label-free imaging of transparent specimens.
Traditional interferometers can be sensitive to environmental vibrations, limiting their practical applications.
Achieving stable and precise phase control is essential for accurate QPM.

Purpose of the Study:

To propose a new common-path and in-line point-diffraction interferometer for QPM.
To enable achromatic phase shifting for improved phase control.
To demonstrate the feasibility of the proposed interferometer design.

Main Methods:

Integration of a grating pair into a point-diffraction interferometer.
Creation of a common-path and in-line configuration for object and reference waves.
Implementation of achromatic phase shifting via linear grating translation.

Main Results:

Successful demonstration of a common-path and in-line interferometer configuration.
Experimental validation of achromatic phase shifting using grating translation.
Confirmation of the interferometer's feasibility for quantitative phase microscopy.

Conclusions:

The proposed common-path, in-line point-diffraction interferometer offers a stable platform for QPM.
Achromatic phase shifting is effectively achieved through a simple grating translation mechanism.
This design presents a viable advancement for high-resolution, vibration-insensitive phase imaging.