Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Hematopoiesis01:21

Hematopoiesis

The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

JAK2<sup>V617F</sup>-positive clonal hematopoiesis in germline BRCA1 versus BRCA2 mutation carriers.

Leukemia·2026
Same author

Mutual inhibition model of pattern formation: The role of Wnt-Dickkopf interactions in driving Hydra body axis formation.

PLoS computational biology·2026
Same author

Exploring a targeted epigenetic clock based on mortality-associated CpGs as a potential biomarker for frailty.

Clinical epigenetics·2026
Same author

Immune aging biomarkers for clinical trials.

Nature medicine·2026
Same author

Modeling, Analysis, and Optimal Control of Leukemic Cell Population Dynamics Under Therapy.

Bulletin of mathematical biology·2026
Same author

Why we age - Integrating error, program, and selective pressure.

Ageing research reviews·2026

Related Experiment Video

Updated: Jun 15, 2026

Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

Modeling of replicative senescence in hematopoietic development.

Anna Marciniak-Czochra1, Thomas Stiehl, Wolfgang Wagner

  • 1Interdisciplinary Center of Scientific Computing (IWR), Institute of Applied Mathematics, University of Heidelberg, Germany.

Aging
|March 3, 2010
PubMed
Summary

Hematopoietic stem cells (HSCs) may not divide indefinitely. A model suggests HSCs can maintain lifelong hematopoiesis despite limited divisions, with aging enhancing self-renewal and stem cell numbers.

Keywords:
aginghematopoietic stem cellsmathematical modelreplicative senescenceself-renewal

More Related Videos

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program
11:00

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program

Published on: December 16, 2016

Related Experiment Videos

Last Updated: Jun 15, 2026

Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program
11:00

Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program

Published on: December 16, 2016

Area of Science:

  • * Hematology
  • * Computational Biology
  • * Cell Biology

Background:

  • * Hematopoietic stem cells (HSCs) generate all blood cells throughout life.
  • * In vitro, HSCs exhibit limited cell divisions before senescence.
  • * The capacity for indefinite HSC rejuvenation versus restricted divisions remains unclear.

Purpose of the Study:

  • * To investigate whether hematopoietic stem cells (HSCs) can rejuvenate indefinitely or if their cell divisions are restricted.
  • * To model the regulation of HSC self-renewal and differentiation during hematopoiesis.
  • * To explore the compatibility of replicative senescence with lifelong hematopoiesis.

Main Methods:

  • * Development of a multi-compartmental model for hematopoietic differentiation using ordinary differential equations.
  • * Hypothesis: Self-renewal versus differentiation is regulated by a single external feedback mechanism at each maturation step.
  • * Simulation of a model with six maturation steps and a 50-division limit for cell proliferation.

Main Results:

  • * Lifelong hematopoiesis is achievable if HSCs possess a slow division rate and high self-renewal rate.
  • * An increasing feedback signal with age enhances HSC self-renewal, boosting stem and progenitor cell numbers.
  • * Model predictions align with experimental observations regarding HSC behavior and aging.

Conclusions:

  • * Replicative senescence is compatible with sustained, lifelong hematopoiesis.
  • * HSCs may not possess an unlimited capacity for cell division.
  • * Findings have potential clinical implications for understanding stem cell behavior and aging.