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Assessment of the Cytotoxic and Immunomodulatory Effects of Substances in Human Precision-cut Lung Slices

Assessment of the Cytotoxic and Immunomodulatory Effects of Substances in Human Precision-cut Lung Slices

Published on: May 9, 2018

Advances in identifying beryllium sensitization and disease.

Dan Middleton¹, Peter Kowalski

¹Division of Health Studies, Agency for Toxic Substances and Disease Registry, Atlanta, GA 30341, USA. dcm2@cdc.gov

International Journal of Environmental Research and Public Health

|March 3, 2010

Summary

Beryllium exposure can cause lung disease. The beryllium lymphocyte proliferation test (BeLPT) helps identify beryllium sensitization (BeS), an early risk factor for chronic beryllium disease (CBD).

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Area of Science:

Occupational Health
Toxicology
Immunology

Background:

Beryllium is a metal with industrial applications.
Occupational exposure to beryllium is linked to lung disease.
Chronic beryllium disease (CBD) arises from hypersensitivity to beryllium.

Purpose of the Study:

To review the identification of beryllium sensitization (BeS).
To discuss the role of the beryllium lymphocyte proliferation test (BeLPT) in assessing BeS.
To explore screening algorithms for BeS.

Main Methods:

Review of historical research linking beryllium exposure to lung disease.
Description of acute and chronic beryllium disease.
Explanation of the beryllium lymphocyte proliferation test (BeLPT).

Keywords:

BeLPT BeS CBD beryllium beryllium sensitization chronic beryllium disease screening

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Main Results:

Beryllium exposure can lead to acute or chronic lung disease.
CBD is typically a hypersensitivity response.
The BeLPT is a key tool for identifying beryllium sensitization (BeS).

Conclusions:

Beryllium sensitization (BeS) indicates a risk for chronic beryllium disease (CBD).
The BeLPT aids in identifying individuals at risk.
Epidemiologic concepts inform screening algorithm development for BeS.