Related Experiment Video
Updated: Jun 15, 2026

Detection of Trypanosoma brucei Variant Surface Glycoprotein Switching by Magnetic Activated Cell Sorting and Flow Cytometry
Published on: October 19, 2016
To switch or not to switch?: Phenotypic switching is sensitive to multiple inputs in a pathogenic fungus
1Department of Molecular Microbiology and Immunology, Brown University, Providence, RI, USA.
Abstract:
Candida albicans is the most commonly isolated human fungal pathogen and uses a diverse repertoire of morphological transitions to aid colonization and infection. In a recent paper we discuss how one of these transitions, the white-to-opaque switch, is affected both by cell stress and by several other conditions that change the rate of cell growth. Based on our findings, we propose that the master regulator of the white-to-opaque switch, WOR1, acts as a sensitive monitor of both intrinsic and environmental conditions.
More Related Videos
11:58The Nematode Caenorhabditis Elegans - A Versatile In Vivo Model to Study Host-microbe Interactions
Published on: October 18, 2017
09:24Use of In Vivo Imaging to Screen for Morphogenesis Phenotypes in Candida albicans Mutant Strains During Active Infection in a Mammalian Host
Published on: October 12, 2022
Related Concept Videos
Transduction
Background and Environment Affect Phenotype
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
Diversity of Protists II
Regulation of Bacterial Virulence
Interactions Between Signaling Pathways
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Frequency-dependent Selection