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Related Experiment Video

Updated: Jun 15, 2026

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses

Published on: August 31, 2014

HLA class I restriction as a possible driving force for Chikungunya evolution.

Joo Chuan Tong¹, Diane Simarmata, Raymond T P Lin

¹Data Mining Department, Institute for Infocomm Research, Fusionopolis, Singapore, Singapore. jctong@i2r.a-star.edu.sg

|March 3, 2010

Summary

Chikungunya virus (CHIKV) evolution shows continuous genotypic lineage and mild positive selection, driven by immune pressure. This research aids understanding of viral epidemiology and vaccine development.

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Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Published on: March 13, 2018

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Last Updated: Jun 15, 2026

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses

Published on: August 31, 2014

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Multiplexed Isothermal Amplification Based Diagnostic Platform to Detect Zika, Chikungunya, and Dengue 1

Published on: March 13, 2018

Area of Science:

Virology
Epidemiology
Immunology

Background:

Chikungunya fever (CHIKF) has resurged globally, causing significant illness and some fatalities.
Phylogenetic analyses of Chikungunya virus (CHIKV) suggest potential increases in pathogenicity during recent epidemics.

Purpose of the Study:

To investigate the evolutionary mechanisms behind CHIKV resurgence.
To understand the impact of host immunity on CHIKV evolution.
To identify potential vaccine targets.

Main Methods:

Extensive phylogenetic and sequence analyses of CHIKV from 1952 to 2009.
Investigation of selective pressures acting on CHIKV evolution.
Analysis of mutations affecting human leukocyte antigen (HLA) class I-restricting elements.

Main Results:

Identified a continuous genotypic lineage in CHIKV, indicating ongoing evolution.
Demonstrated mild positive selection acting on CHIKV.
Observed site-specific mutations potentially driven by cell-mediated immune pressure, including loss of HLA class I-restricting elements.

Conclusions:

CHIKV evolution is influenced by selective pressures, particularly host immune responses.
Post-genomic analyses are powerful tools for understanding viral epidemiology.
Findings can inform the development of subunit vaccines against CHIKV.