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Updated: Jun 15, 2026
08:12
A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage
Published on: July 28, 2018
6-Mercaptopurine attenuates adhesive molecules in experimental vasospasm
Chih-Zen Chang1, Chih-Lung Lin, Neal F Kassel
1Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China. chzech@kmu.edu.tw
Acta Neurochirurgica
|March 3, 2010
Summary
6-mercaptopurine (6-mp) treatment reduced elevated levels of intercellular adhesion molecule-1 (ICAM-1) and E-selectin following subarachnoid hemorrhage (SAH). This reduction in adhesion molecules may contribute to 6-mp
Area of Science:
- Neuroscience
- Immunology
- Pharmacology
Background:
- Adhesion molecules like ICAM-1, VCAM-1, and E-selectin are elevated after aneurysmal subarachnoid hemorrhage (SAH).
- Previous research indicated 6-mercaptopurine (6-mp) prevents and reverses arterial narrowing in a rodent SAH model.
Purpose of the Study:
- To investigate the effect of 6-mp on adhesion molecule levels in a rodent SAH model.
- To determine if 6-mp alters ICAM-1, VCAM-1, and E-selectin serum concentrations post-SAH.
Main Methods:
- Rodents underwent SAH induction via autologous blood injection.
- 6-mp treatment was administered pre-SAH (prevention) or post-SAH (treatment).
- Serum levels of ICAM-1, VCAM-1, and E-selectin were measured at 72 hours post-SAH.
Main Results:
- SAH induced significant increases in ICAM-1 and E-selectin levels.
- 6-mp treatment (preventive and therapeutic) normalized ICAM-1 levels.
- 6-mp treatment prevented the SAH-induced increase in E-selectin levels, while VCAM-1 levels showed no significant change.
Conclusions:
- ICAM-1 and E-selectin play a role in SAH-induced vasospasm.
- Reduced levels of ICAM-1 and E-selectin may contribute to the anti-spastic effects of 6-mp.
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