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Related Concept Videos

Role of Septins01:02

Role of Septins

Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate filaments. These proteins can associate with other cytoskeletal filaments and carry out varied roles or can be free-floating in the cytoplasm.
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
Septins01:19

Septins

Septins are protein filaments forming the cytoskeleton along with the microtubules, microfilaments, intermediate filaments, and other accessory proteins. In 1971 while studying the cell division cycle in mutant Saccharomyces cerevisiae Harwell et al. first identified the septin-related genes playing a crucial role in yeast cytokinesis. Fluorescence microscopy revealed that these proteins localize at the budding neck as rings. These ring-like proteins were then named Septins by John Pringle, and...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...

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Related Experiment Video

Updated: Jun 15, 2026

Purification and Quality Control of Recombinant Septin Complexes for Cell-Free Reconstitution
11:50

Purification and Quality Control of Recombinant Septin Complexes for Cell-Free Reconstitution

Published on: June 23, 2022

Linking the septin expression with carcinogenesis.

Ming Liu1, Suqin Shen, Fang Chen

  • 1State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai, 200433, People's Republic of China.

Molecular Biology Reports
|March 3, 2010
PubMed
Summary
This summary is machine-generated.

Septins, a family of GTP-binding proteins, show altered expression in many cancers. Specific septins like SEPT2 and SEPT9 are upregulated, while SEPT4 is downregulated, suggesting their role in cancer development.

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Area of Science:

  • Molecular Biology
  • Oncology

Background:

  • Septins are conserved GTP-binding proteins crucial for various cellular functions.
  • Aberrant septin expression is linked to carcinogenesis and tumor development.

Purpose of the Study:

  • To investigate the expression patterns of 14 human septin family members across 35 tumor types.
  • To correlate septin expression with tumor malignancy and patient prognosis.

Main Methods:

  • Utilized the ONCOMINE microarray database for comparative analysis.
  • Examined expression levels of 14 human septin genes in tumor tissues versus normal counterparts.

Main Results:

  • Most septin family members exhibited altered expression in numerous cancer types.
  • SEPT2, SEPT8, SEPT9, and SEPT11 were consistently upregulated, while SEPT4 and SEPT10 were downregulated across most investigated cancers.
  • Observed correlations between abnormal septin expression and tumor grade or patient survival outcomes.

Conclusions:

  • Septins represent a group of cancer-critical genes with potential roles as oncogenes or tumor suppressors.
  • Findings support the involvement of septins in cancer development and progression.