Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epistasis Analysis01:09

Epistasis Analysis

Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
Epistasis01:39

Epistasis

In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
Pharmacokinetics: Drug–Drug Interactions01:25

Pharmacokinetics: Drug–Drug Interactions

Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A cross-sectional analysis of male versus female flourishing among 202,898 participants across 22 countries on 73 variables in the global flourishing study.

Scientific reports·2026
Same author

Spirituality and Harmful or Hazardous Alcohol and Other Drug Use: A Meta-Analysis of Longitudinal Studies.

JAMA psychiatry·2026
Same author

Love of neighbor assessment: validity, reliability, and a template for measurement.

Frontiers in psychology·2026
Same author

Childhood experiences and adult self-rated physical health in 22 countries.

BMC global and public health·2026
Same author

Mental illness, mental health, and mental well-being.

Npj mental health research·2026
Same author

Adolescence in social context: Longitudinal associations of 15 social factors with health and well-being.

Social science & medicine (1982)·2026

Related Experiment Video

Updated: Jun 15, 2026

A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe
07:55

A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe

Published on: March 7, 2019

Epistatic interactions.

Tyler J VanderWeele1

  • 1Harvard University, USA. tvanderw@hsph.harvard.edu

Statistical Applications in Genetics and Molecular Biology
|March 4, 2010
PubMed
Summary

Epistasis describes genetic interactions, sometimes masking variant effects. New methods exploit data patterns to empirically test for this masking form of epistasis.

Area of Science:

  • Genetics
  • Statistical Genetics

Background:

  • Epistasis is variably defined, encompassing statistical interactions and masking effects of genetic variants.
  • Current statistical tests for interaction have limited utility in detecting epistasis specifically as the masking of genetic variant effects.

Purpose of the Study:

  • To explore novel relations between empirical data patterns and epistasis.
  • To develop methods for empirically testing epistasis in the context of masking effects.

Main Methods:

  • Analysis of empirical data patterns to identify previously unrecognized relationships with epistasis.
  • Development and application of statistical approaches to detect epistasis through variant masking.

Main Results:

  • Identified new empirical data patterns linked to epistasis.

More Related Videos

Using Caenorhabditis elegans to Screen for Tissue-Specific Chaperone Interactions
06:55

Using Caenorhabditis elegans to Screen for Tissue-Specific Chaperone Interactions

Published on: June 7, 2020

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays
14:06

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays

Published on: November 12, 2012

Related Experiment Videos

Last Updated: Jun 15, 2026

A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe
07:55

A Deep-sequencing-assisted, Spontaneous Suppressor Screen in the Fission Yeast Schizosaccharomyces pombe

Published on: March 7, 2019

Using Caenorhabditis elegans to Screen for Tissue-Specific Chaperone Interactions
06:55

Using Caenorhabditis elegans to Screen for Tissue-Specific Chaperone Interactions

Published on: June 7, 2020

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays
14:06

Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays

Published on: November 12, 2012

  • Demonstrated that these patterns can be leveraged to empirically test for epistasis, particularly the masking of genetic variant effects.

    • Conclusions:

    • Novel empirical data patterns are related to epistasis.
    • These findings enable new empirical tests for epistasis, specifically addressing the masking of genetic variant effects by other loci.