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The Nucleolus

The Nucleolus

The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...

The Nucleolus

The Nucleolus

The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...

Single Nucleotide Polymorphisms-SNPs

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...

Ribosomal RNA Synthesis

Ribosomal RNA Synthesis

Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
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Additional Subnuclear Structures

Additional Subnuclear Structures

The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals.
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles, paraspeckles, etc. These nuclear...

Nuclear Protein Sorting

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Nuclear protein sorting is the selective trafficking of histones, polymerases, gene regulatory proteins into the nucleus and exporting RNAs and ribosomes to the cytosol. It is a tightly controlled process that regulates gene expression within a cell.
Proteins targeted to the nucleus carry nuclear localization signals or NLS recognized by import receptors in the cytosol. Similarly, proteins with nuclear export signals are recognized by export receptors. Import and export receptors are...

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Related Experiment Video

Updated: Jun 15, 2026

Sample Preparation for Mass Spectrometry-based Identification of RNA-binding Regions

Sample Preparation for Mass Spectrometry-based Identification of RNA-binding Regions

Published on: September 28, 2017

The small nucleolar ribonucleoprotein (snoRNP) database.

J Christopher Ellis¹, Daniel D Brown, James W Brown

¹Department of Biology, Duke University, Durham, North Carolina 27708, USA.

RNA (New York, N.Y.)

|March 4, 2010

Summary

This summary is machine-generated.

The snoRNP database now houses 8994 small nucleolar RNA (snoRNA) sequences and 589 associated proteins. This resource aids researchers in exploring snoRNA diversity across species.

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Identification of Footprints of RNA:Protein Complexes via RNA Immunoprecipitation in Tandem Followed by Sequencing (RIPiT-Seq)

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Published on: July 10, 2019

Area of Science:

Molecular Biology
Bioinformatics
Genomics

Background:

Small nucleolar ribonucleoproteins (snoRNPs) are crucial for modifying ribosomal RNAs (rRNAs) and have roles in tRNA modification and mRNA splicing.
Advancements in bioinformatics enable rapid identification of noncoding RNAs, including snoRNAs, from genomic data.
This has led to a significant increase in the discovery of diverse snoRNA sequences.

Purpose of the Study:

To establish a centralized, web-based repository for snoRNA and associated protein sequences.
To provide a comprehensive resource for researchers studying snoRNP function and evolution across different species.

Main Methods:

Development of a web-based database.
Collection and curation of snoRNA and snoRNP-associated protein sequences from diverse species.
Bioinformatic analysis of genomic and metagenomic data for snoRNA identification.

Main Results:

The snoRNP database contains 8994 snoRNA sequences and 589 snoRNA-associated protein sequences.
The database covers sequences from Bacteria, Archaea, and Eukaryotes.
The database is accessible online at http://evolveathome.com/snoRNA/snoRNA.php.

Conclusions:

The snoRNP database serves as a valuable resource for the scientific community.
It facilitates research into the function, diversity, and evolution of snoRNAs and snoRNPs.
The database supports ongoing efforts in noncoding RNA research.