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Impact of mycophenolate mofetil on wound complications and lymphoceles after kidney transplantation

Kai Lopau1, Karin Syamken, Peter Rubenwolf

  • 1Department of Internal Medicine I, Division of Nephrology, University of Wuerzburg, Wuerzburg, Germany. lopau_k@klinik.uni-wuerzburg.de

Kidney & Blood Pressure Research
|March 4, 2010
PubMed
Abstract

Insights

Mycophenolate mofetil (MMF) use in transplant patients was linked to increased lymphocele formation compared to azathioprine (AZA). This finding highlights potential risks associated with MMF, necessitating careful patient monitoring.

Area of Science:

  • Transplantation immunology
  • Surgical outcomes
  • Pharmacovigilance

Background:

  • Modern immunosuppressive agents, while effective, can present unexpected side effects.
  • Investigating the impact of mycophenolate mofetil (MMF) on wound healing and lymphocele formation is crucial.

Purpose of the Study:

  • To compare the incidence of lymphocele formation and non-primary wound healing between patients treated with MMF and azathioprine (AZA).
  • To identify potential risks associated with MMF in post-transplant care.

Main Methods:

  • Retrospective single-center analysis of 144 patients on cyclosporine A-based immunosuppression.
  • Patients received either MMF (n=77) or AZA (n=77) alongside prednisolone.
  • Endpoints included lymphocele formation and non-primary wound healing over 6 months.

Main Results:

  • The MMF group showed a significantly higher incidence of fluid accumulation around the graft (lymphoceles) compared to the AZA group (OR=2.6, p=0.03).
  • MMF patients required more interventions for fluid collection, including drainage and sclerotherapy.
  • No significant difference in graft loss or function was observed; AZA patients had a trend towards more wound infections.

Conclusions:

  • A potential association exists between MMF administration and increased lymphocele formation.
  • Awareness and monitoring are essential for patients on MMF to mitigate risks like reinterventions and prolonged hospitalization.

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