Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 10, 2026

Directed Cellular Self-Assembly to Fabricate Cell-Derived Tissue Rings for Biomechanical Analysis and Tissue Engineering
08:00

Directed Cellular Self-Assembly to Fabricate Cell-Derived Tissue Rings for Biomechanical Analysis and Tissue Engineering

Published on: November 25, 2011

Modular self-assembling biomaterials for directing cellular responses.

Joel H Collier1

  • 1Joel H. Collier, Ph.D., Assistant Professor, Department of Surgery and Committee on Molecular Medicine, University of Chicago, 5841 S. Maryland Ave, Abbott Hall AB522, Chicago, IL 60637 USA, collier@uchicago.edu.

Soft Matter
|March 4, 2010
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immunomodulatory biomaterials for treating chronic inflammation at mucosal sites.

npj biomedical innovations·2025
Same author

Presentation of hemagglutinin on adjuvant-bearing self-assembling peptide nanofibers increases heterologous responses against influenza.

Acta biomaterialia·2025
Same author

Differential Sensitivity to Interepitope Spacing in Mast Cells and B Cells Enables Design of Hypoallergenic Allergen Vaccine Immunogens.

ACS nano·2025
Same author

Tuning Helical Peptide Nanofibers as a Sublingual Vaccine Platform for a Variety of Peptide Epitopes.

Advanced healthcare materials·2024
Same author

Multi-Target Peptide Nanofiber Immunotherapy Diminishes Complement Anaphylatoxin Activity in Acute Inflammation.

Advanced healthcare materials·2024
Same author

Anti-Cytokine Active Immunotherapy Based on Supramolecular Peptides for Alleviating IL-1β-Mediated Inflammation.

Advanced healthcare materials·2024
Same journal

Nanopore sequencing with proteins: synchronization and dischronization of molecular dynamics simulations with laboratory and industrial developments.

Soft matter·2026
Same journal

Catanionics from biosurfactants and regular surfactants: miscibility and structure.

Soft matter·2026
Same journal

Adhesives with a thickness smaller than the fractocohesive length enhance adhesion.

Soft matter·2026
Same journal

Non-equilibrium phase transitions in hybrid Voronoi models of cell colonies.

Soft matter·2026
Same journal

Effects of methoxy substituents on self-assembly and gelation performance of benzamide-based organogelators.

Soft matter·2026
Same journal

Rheology of <i>Escherichia coli</i> suspensions with various bacterial morphologies and motion characteristics.

Soft matter·2026
See all related articles

Modular self-assembling biomaterials offer tunable properties for advanced cell-interactive matrices. Researchers are optimizing these materials for 3-D cell culture and regenerative medicine, addressing challenges in immune system interaction.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Cell Biology

Background:

  • Self-assembling biomaterials offer modular construction for fine-tuning properties.
  • This modularity is key for optimizing multi-component matrices in complex biological settings.
  • Applications include 3-D cell culture and regenerative medicine scaffolds.

Purpose of the Study:

  • To review recent strategies for creating modular self-assembling biomaterials.
  • To focus on the modular control of ligand presentation and matrix mechanics.
  • To identify challenges in using these materials for biomedical applications, including immune system interactions.

Main Methods:

  • Discussion of recent literature on modular self-assembling biomaterials.
  • Analysis of strategies for controlling ligand presentation.

More Related Videos

Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold
07:09

Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold

Published on: October 26, 2018

Fabrication and Characterization of Colorectal Cancer Organoids from SW1222 Cell Line in Ultrashort Self&#45;Assembling Peptide Matrix
10:23

Fabrication and Characterization of Colorectal Cancer Organoids from SW1222 Cell Line in Ultrashort Self-Assembling Peptide Matrix

Published on: May 3, 2024

Related Experiment Videos

Last Updated: Jun 10, 2026

Directed Cellular Self-Assembly to Fabricate Cell-Derived Tissue Rings for Biomechanical Analysis and Tissue Engineering
08:00

Directed Cellular Self-Assembly to Fabricate Cell-Derived Tissue Rings for Biomechanical Analysis and Tissue Engineering

Published on: November 25, 2011

Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold
07:09

Manipulating Living Cells to Construct Stable 3D Cellular Assembly Without Artificial Scaffold

Published on: October 26, 2018

Fabrication and Characterization of Colorectal Cancer Organoids from SW1222 Cell Line in Ultrashort Self&#45;Assembling Peptide Matrix
10:23

Fabrication and Characterization of Colorectal Cancer Organoids from SW1222 Cell Line in Ultrashort Self-Assembling Peptide Matrix

Published on: May 3, 2024

  • Examination of methods for tuning matrix mechanics.

    • Main Results:

    • Modular design enables independent tuning of physicochemical and biological properties.
    • Strategies exist for modular control over ligand presentation and matrix mechanics.
    • Key challenges remain in interfacing these materials with the immune system.

    Conclusions:

    • Modular self-assembling biomaterials are highly promising for cell-interactive applications.
    • Further research is needed to overcome hurdles related to biological integration and immune response.
    • Optimized materials will advance 3-D cell culture and regenerative medicine.