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Synthesis, characterization, and biological screening of a copper flurbiprofen complex with anti-inflammatory effects
S Oga1, S F Taniguchi, R Najjar
1Departamento de Farmacologia do Instituto de Ciências Biomédicas, Universidade de São Paulo, Brazil.
Journal of Inorganic Biochemistry
|January 1, 1991
Abstract:
The flurbiprofen complex of copper(II) was prepared and characterized by IR, UV-VIS and EPR Spectroscopy, magnetic susceptibility, and thermogravimetric analysis. The compound was tested for in vivo anti-inflammatory and analgesic activities in rats. The inhibitory effect on carrageenin-induced paws inflammation and analgesic effect of copper flurbiprofen complex were similar to those of free flurbiprofen. However, the copper complex produced less gastric irritation than the parent drug.