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Related Experiment Videos

Mortality rates from multiple sclerosis: geographical and temporal variations revisited.

E S Williams1, D R Jones, R O McKeran

  • 1Department of Public Health Medicine, Croydon General Hospital, UK.

Journal of Neurology, Neurosurgery, and Psychiatry
|February 1, 1991
PubMed
Summary

Multiple Sclerosis (MS) mortality rates declined significantly in the UK over 30 years, with Scotland showing a greater reduction. This suggests environmental factors may influence MS causes.

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Area of Science:

  • Neurology
  • Epidemiology
  • Public Health

Background:

  • Multiple Sclerosis (MS) is a chronic neurological disease.
  • UK literature indicates rising MS prevalence and incidence over recent decades.
  • Simultaneously, MS mortality rates have shown a declining trend.

Purpose of the Study:

  • To analyze temporal and geographical variations in UK MS mortality over 30 years.
  • To estimate changes in MS patient survival rates.
  • To investigate the relationship between MS mortality and morbidity trends.

Main Methods:

  • Review of United Kingdom mortality data spanning a 30-year period.
  • Analysis of temporal trends in MS-related deaths.
  • Examination of geographical differences in MS mortality, particularly between Scotland and England/Wales.

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Main Results:

  • Overall UK MS mortality declined by approximately 25% by 1983.
  • A notable reduction in the mortality gap between Scotland and England/Wales was observed.
  • No significant correlation was found between MS mortality and morbidity trends.
  • Median age of death increased from 52 to 59 years.
  • Scotland experienced a 39% decline in deaths, compared to 10% in England and Wales.

Conclusions:

  • The declining MS mortality rates and differential reduction between Scotland and England/Wales may offer crucial etiological insights.
  • The observed rate of decline suggests an environmental, rather than genetic, cause for Multiple Sclerosis.
  • Improvements in survival rates did not significantly contribute to the reduced mortality differential.